Posted by SANUSq Research Team on 7/1/2021 to Health articles
What are the health benefits of resveratrol?
Resveratrol has been the subject of many recent studies aiming to understand the life-lengthening abilities of this powerful antioxidant. The results are excellent, suggesting that it can effectively reduce the risk of chronic diseases.
Resveratrol Fast Facts
- Resveratrol is a polyphenol, a micronutrient found in plants.
- Certain plants produce resveratrol to help with survival against stressors such as fungal infection, UV exposure, disease, extreme climate, and lack of nutrients.
- Resveratrol is found in grapes, berries, peanuts, green tea, and dark chocolate.
Let’s discover and discuss the top 5 best health benefits of resveratrol.
1. It is an excellent anti-aging ingredient
Resveratrol is a favored anti-aging ingredient that helps to fight oxidative stress and its visible and medical effects. It does so by scavenging free radicals and activating sirtuins, (special enzymes involved in overall health and longevity).
Resveratrol as an antioxidant: if you’ve ever searched for anti-aging products, you’ll be familiar with the idea of oxidative stress caused by free radicals.
Free radicals are produced by your body as a by-product of cellular reactions such as energy creation or immune cells fighting pathogens. Free radical production is also increased by external factors such as exposure to toxins, certain medications, excessive alcohol consumption, chronic infection, and even emotional stress.
So, how do free radicals accelerate the ageing process? They cause oxidative damage to cells and their components, including lipids and mitochondria. This damage triggers immune responses, causing inflammation and damage to cells, organs, and tissues. Antioxidants come to the rescue by destroying these free radicals, limiting the oxidative damage caused to the body.
The human body has a built-in antioxidant system (endogenous antioxidants) designed to keep oxidation and inflammation at bay. Resveratrol boosts these antioxidants already present in your body, creating an even stronger free-radical-fighting network. As studies show, it could be even more effective than well-known and beloved vitamins C and E.
Resveratrol activates sirtuins:
SIRT1 is a member of the sirtuin family, a group of proteins. These enzymes regulate cellular processes that affect energy metabolism, inflammation, immune function, DNA repair, circadian rhythms, mitochondrial function, and cellular stress response.
Research shows that resveratrol activates SIRT1, helping to prevent inflammation-related disease, metabolic disorders, and aid in DNA repair. Another surprising way to boost sirtuin activation is to reduce caloric intake (as long as you get sufficient nutrition for your body’s functions).
Sirtuins are also influential in the production and role of mitochondria, the organelles that provide energy for every cell. These clever organelles produce energy by burning carbs, proteins, and fats that you consume. This energy-producing process also creates an unfortunate by-product, free radicals. Therefore, mitochondria and their DNA are in the firing line of these free radicals, causing destruction and damage. Such damage leads to poor mitochondrial health and function, leading to age-related diseases.
The good news is that resveratrol not only supports sirtuins (and therefore mitochondria) but also boosts the levels of antioxidants located in the mitochondria.The age-related benefits of resveratrol continue. Studies show that it may revive senescent cells, cells that become old and therefore unable to divide. The accumulation of such cells can contribute to the development of chronic diseases that we typically experience as we age. 
2. Resveratrol supports a healthy heart
Resveratrol is a heart-loving antioxidant that reduces oxidative damage and reduces inflammation. It is important to note that oxidative stress reduces the availability of nitric oxide (NO), an important molecule in the regulation of endothelial health and function. Your arterial walls are lined with a layer of cells (endothelium), and they are susceptible to issues such as inflammation, atherosclerosis, and heart disease. NO is important for heart health as it helps the blood vessels to dilate and relax, aiding in healthy blood pressure.
Resveratrol supports heart health by:
- Preventing oxidation of low-density lipoproteins (LDL), one of the key culprits in heart disease development
- Improving endothelial function by boosting levels of NO 
- Boosts the level of antioxidant enzymes in cells, reducing heart-based oxidative stress
- Helps to prevent blood clot formation
More comprehensive, long-term clinical trials are required to learn more about the role of resveratrol as an antioxidant and a mitochondria booster. However, the research we do have is very promising.
This review reported that, “This polyphenolic compound reduces mitochondrial superoxide generation by stimulating mitochondria biogenesis. Resveratrol prevents superoxide production from uncoupled endothelial nitric oxide synthase by up-regulating the tetrahydrobiopterin-synthesizing enzyme GTP cyclohydrolase I. In addition, resveratrol increases the expression of various antioxidant enzymes.” 
Another review stated that “taking into account the beneficial effects of RES on hypertension, obesity, inflammation, diabetes and dyslipidemia, RES could constitute an interesting pharmacological approach for the treatment of metabolic syndrome, which is associated with an increased risk of CVD development.” 
3. Resveratrol supports brain health
One of the best resveratrol health benefits concerns brain health and cognitive function thanks to its antioxidant and anti-inflammatory properties.
The brain requires huge amounts of energy, meaning it is constantly exposed to free radicals produced by mitochondria in the energy production process. Therefore, this crucial organ is very susceptible and vulnerable to oxidative damage.
The burning question is, can resveratrol reduce the risk of Alzheimer’s? The answer is positive. Because it reduces inflammation in the brain, resveratrol may curb the progression of this devastating neurodegenerative disease.
More specifically, a 2017 study discovered that resveratrol preserves the integrity of the blood-brain barrier in Alzheimer’s sufferers. This means that inflammatory molecules are prevented from reaching brain tissue, where they would cause brain inflammation and neuron destruction.  Researchers also found that patients who were given resveratrol had reduced levels of matrix metalloproteinase-9 (MMP-9) in their cerebrospinal fluid. MMP-9 can lead to a faulty blood-brain barrier, allowing external (outside the brain) proteins and molecules to enter the brain and cause damage.
Resveratrol also boosts proactive molecules that help your adaptive immune system to break down and expel abnormal proteins that cause brain damage. According to the researchers “This is the kind of immune response you want — it is there to remove and degrade neurotoxic proteins.” 
It is important to note that the researchers specified that resveratrol can’t aid Alzheimer’s patients alone, but it certainly plays an important part.
4. Resveratrol helps in Type 2 diabetes management
Resveratrol, type 2 diabetes, and weight loss have been positively linked. It has been found to lower blood glucose and insulin resistance in type 2 diabetes patients.   
Resveratrol’s anti-inflammatory and antioxidant abilities are a key part of these health benefits. However, there are other mechanisms at play that make resveratrol a supporter of metabolic function. 
Firstly, resveratrol activates Sirtuin1, helping to improve insulin sensitivity in cells. SIRT1 (located mainly in the nucleus) controls the release of insulin from the pancreas’ beta cells. Insulin is a crucial hormone as it helps the cells to process and use glucose in the blood, regulating blood sugar levels. SIRT1 is also handy as it protects the insulin-secreting beta cells from damage caused by aging, inflammation, and metabolic stress. It is the activation of SIRT1 that may be the reason why it is so helpful in reducing arterial stiffness caused by aging, type 2 diabetes, and excess weight.
Secondly, it boosts AMP-activated protein kinase (AMPK), an enzyme that controls how the body uses fat and glucose.
This increase in AMPK action reduces the risk of obesity and its associated health issues.
Thirdly, it boosts NO levels, therefore improving endothelial function and improving insulin resistance.
New research has shed light on another possible way that resveratrol helps to prevent metabolic disorders.
A 2018 study reveals that resveratrol has a good relationship with gut microbiota, changing the bacterial arrangement in a way that is linked with “beneficial metabolic outcomes”. 
Another study published by the American Heart Association in 2017 reported that it may help to reduce arterial stiffness in type 2 diabetes patients.  High blood glucose levels cause arterial inflammation and damage, leading to stiffness. Age is also a strong factor in arterial stiffness. However, people with diabetes can experience premature hardening of arteries, leading to increased risk of health issues such as high blood pressure, stroke, and heart attack.
As we have learned, excess blood glucose leads to inflammation and blood vessel damage, causing both large and small blood vessels to malfunction. This negatively affects heart health but also impairs brain health by weakening blood flow to the brain, boosting the risk of dementia in type 2 diabetes patients.
5. Resveratrol benefits for skin health
We’ve already discovered how resveratrol can activate important proteins in overall health and longevity. However, resveratrol benefits for skin are just as promising. UV radiation (via sun exposure) boosts the production of free radicals that damage cells, including their lipids and DNA.
Excess sun exposure can lead to premature ageing of the skin, causing fine lines, wrinkles, and dry skin. What’s more, free radicals hinder the production of collagen, the protein that gives your skin that youthful appearance and elasticity.
How does resveratrol support healthy skin?
- Protects the skin against UV rays and subsequent oxidative stress.
- Helps the repairing process
- Supports collagen synthesis (the building block of skin
The best resveratrol supplements
Taking a high-quality resveratrol supplement is an excellent way to reduce your risk of disease and fight the aging process.However, the wonderful health benefits are inhibited by your body’s digestive system. It is very quickly digested by the body, which does not allow enough time for the nutrients to be properly absorbed.To combat this, you can take it in liposomal form. Liposomes provide a safe casing for the resveratrol to be delivered slowly and thoroughly, offering maximum health benefits.Visit these pages to understand more about liposomes:
- E Latorre et al. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biology. 2017
- Xia et al. Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue. Ann N Y Acad Sci. 2017
- Ning et al. Antioxidant effects of resveratrol in the cardiovascular system. British Journal of Pharmacology. 2016.
- Dominique Bonnefont-Rousselot et al. Resveratrol and Cardiovascular Diseases. Nutrients. 2016.
- Moussa et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. Journal of Neuroinflammation 2017
- Press Release. Resveratrol Appears to Restore Blood-Brain Barrier Integrity in Alzheimer’s Disease. Georgetown University Medical Centre. 2016.
- Zhu et al. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab (Lond). 2017
- Liu et al. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr. 2014
- Goh et al. Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure. Int J Sport Nutr Exerc Metab. 2014.
- Wong et al. Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation. Nutrients. 2018
- Chaplin et al. Resveratrol, Metabolic Syndrome, and Gut Microbiota. Nutrients 2018.
- Can the antioxidant resveratrol reduce artery stiffness in diabetics? American Heart Association. 2017.
- Wong et al. Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus. Nutrition Metabolism & Cardiovascular Diseases. 2016.